Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections).
Interventional study. Background: - Some children experience a sudden onset of symptoms similar to those found in obsessive-compulsive disorder that may be caused by the body's reaction to an infection with streptococcal bacteria, most commonly seen as strep throat or scarlet fever. Ages 4-12. Locations in New Haven, CT; Bethesda, MD; Oklahoma City, OK.
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PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A.
Interventional study. Background: - A small brain protein called nociceptin/orphanin FQ peptide (NOP) receptor may be involved in several brain diseases such as anxiety, depression, drug abuse, and seizures. Ages 18-50. Location in Bethesda, MD.
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Brain Markers of Anxiety Disorders and SSRI Treatment in Children and Adolescents.
Interventional study. This study will attempt to identify gene and brain activity markers that predict whether children and adolescents with anxiety disorders will respond to selective serotonin reuptake inhibitor medications. Ages 7-19. Location in Ann Arbor, MI.
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PET Whole Body Distribution Studies Using [11C]CUMI.
Evaluation study. Background: - Researchers studying new treatments for major depressive disorder are looking at how medications to treat depression act on the brain chemical serotonin, which interacts with specific serotonin receptors on brain cells. Ages 18-65. Location in Bethesda, MD.
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Effects of a CRF1 Receptor Antagonist on Human Startle in Normal Female Volunteers.
Evaluation study. Background: - Research has shown that the hormone corticotropin-releasing hormone (CRH) is involved in stress and anxiety, and that drugs that block the effect of CRH in the body can reduce anxiety. Ages 21-50. Location in Bethesda, MD.
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Anxiety and Recurrent Abdominal Pain in Children.
Interventional study. This study aims to determine whether citalopram is a useful, well-tolerated, and safe treatment for children and adolescents ages 7 to 18 years with functional abdominal pain. Ages 7-18. Location in Columbus, OH.
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RCT of an Acceptance-based Behavior Therapy for GAD.
Interventional study. The purpose of this study is to determine whether acceptance-based behavior therapy for GAD results in greater symptom reduction and increased quality of life than applied relaxation. Ages 18 and over. Location in Boston, MA.
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Neural Functioning Underlying Anxiety and Its Treatment (The INSULA Study).
Interventional study. This study will examine the effects of cognitive behavioral therapy on brain function in people with anxiety disorders. Ages 18-55. Location in La Jolla, CA.
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Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety.
Interventional study. This study will examine the feasibility and efficacy of a personalized psychotherapy treatment for people with depression and co-occurring anxiety. Ages 18-65. Location in Pittsburgh, PA.
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Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes.
Evaluation study. By testing physiological responses to anxiety in people with nervous system developmental disorders, this study will identify specific physiological characteristics associated with response to anxiety treatments. Ages 5-25. Location in Sacramento, CA.
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Examining Long-Term Effects and Neural Mediators of Behavioral Treatments for Social Anxiety Disorder.
Interventional study. This study will compare the effects that two types of behavioral therapy have on brain function in people with social anxiety disorder. Ages 18-45. Location in Los Angeles, CA.
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Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder.
Interventional study. This study will attempt to identify gene and brain activity markers that predict whether people with social anxiety disorder will respond to selective serotonin reuptake inhibitor medications. Ages 18-55. Location in Ann Arbor, MI.
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Effectiveness of a Family-Based Treatment for Preventing Anxiety Disorders in At-Risk Children.
Interventional study. This study will test the effectiveness of a family-based behavioral program for preventing anxiety disorders in at-risk children. Ages 7-12. Location in Baltimore, MD.
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Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder.
Interventional study. Pediatric Bipolar Disorder (BD) is uncommon in children. Ages 9-17. Location in Bethesda, MD.
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Assessing Different Methods of Anxiety Care in Pediatric Settings.
Interventional study. This study will compare the effectiveness of delivering cognitive behavioral therapy for children with anxiety disorders through in-person contact versus through workbooks and telephone communication. Ages 8-13. Location in San Diego, CA.
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Effectiveness of Emotion-Focused Cognitive Behavioral Therapy for Treating Adolescents With Emotional Disorders.
Interventional study. This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders. Ages 12-17. Location in Miami, FL.
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Cognitive Behavioral Therapy With Parental Involvement for Treating Children With Anxiety Disorders.
Interventional study. This study will compare the effectiveness of individual cognitive behavioral therapy with two distinct types of parent involvement versus individual cognitive behavioral therapy without parent involvement in treating children with anxiety disorders. Ages 8-11. Location in Miami, FL.
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Antidepressant Treatment Plus Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults.
Interventional study. This study will assess whether adding cognitive behavioral therapy to the antidepressant escitalopram is effective in reducing anxiety in older adults with generalized anxiety disorder. Ages 60 and over. Locations in San Diego, CA; St. Louis, MO.
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School-Based Treatment for Anxious Children.
Interventional study. This study will determine the effectiveness of a school-based cognitive behavior therapy in urban, predominantly low-income, African-American children diagnosed with an anxiety disorder. Ages 7-17. Location in Baltimore, MD.
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Evaluating the Effects of Stress in Pregnancy.
Evaluation study. This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy. Ages 18-45. Location in Atlanta, GA.
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Pharmacogenomics of Antidepressant Response in Children and Adolescents.
Evaluation study. This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications. Ages 7-17. Location in Durham, NC.
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Evaluating Parenting Styles and Child Temperament Associated With Child Anxiety Disorders.
Evaluation study. This study will look at similarities and differences in family processes and child temperament among children with and without symptoms of anxiety disorders. Ages 8-12. Location in Providence, RI.
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Effect of D-Cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia.
Interventional study. This study will assess the effectiveness of D-cycloserine combined with cognitive-behavior therapy in treating people with social anxiety disorder. Ages 18 and over. Location in Boston, MA.
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Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias.
Interventional study. This study will compare the effectiveness of two types of cognitive behavioral therapy, one-session exposure treatment and family-enhanced one-session exposure treatment, in treating children with specific phobias. Ages 7-12. Location in Blacksburg, VA.
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Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses.
Interventional study. This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses. Ages 18-70. Location in Baltimore, MD.
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Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy.
Interventional study. This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes. Ages 21-45. Location in Ann Arbor, MI.
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Comparison of Psychotherapy Programs to Treat Panic Disorder.
Interventional study. This study will determine the relative effectiveness of three psychotherapies in treating people with a panic disorder. Ages 18-70. Locations in New York, NY; Philadelphia, PA.
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Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder.
Interventional study. This study will assess the relapse-prevention rate of escitalopram (Lexapro) in the treatment of body dysmorphic disorder. Ages 18 and over. Locations in Boston, MA; Providence, RI.
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Use of an Antibiotic as an Enhancer for the Treatment of Social Phobia.
Interventional study. This study examines whether an antibiotic, d-cycloserine (DCS), boosts the effectiveness of cognitive behavior therapy (CBT) for social anxiety. Ages 8-55. Location in Bethesda, MD.
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Preventing Anxiety Disorders in Youth.
Interventional study. This study will determine the effectiveness of a cognitive behavioral therapy program in preventing anxiety disorders in at-risk children. Ages 8-12. Location in Baltimore, MD.
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Family Study of Affective and Anxiety Spectrum Disorders.
Evaluation study. This study will examine how depression, anxiety, and migraine run in families. Ages up to 60. Location in Bethesda, MD.
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Generalized Anxiety Disorder and Social Anxiety Disorder: Their Impact on the Processing of Information and Learning.
Evaluation study. The purpose of this study is to increase researchers' understanding of the biological basis of generalized anxiety disorder and social anxiety disorder. Ages 18-50. Location in Bethesda, MD.
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The Psychobiology of Childhood Temperament.
Evaluation study. The purpose of this study is to use brain imaging technology to examine brain changes that occur in children when they are exposed to various kinds of emotional tasks and to determine if these changes are related to the child's temperament. Ages 7-25. Locations in Bethesda, MD; College Park, MD.
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Expectation of Unpleasant Events in Anxiety Disorders.
Evaluation study. Fear and anxiety are normal responses to a threat. Ages 18-60. Location in Bethesda, MD.
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Brain Changes in Fear.
Evaluation study. The purpose of this study is to use brain imaging technology to investigate brain changes in people exposed to predictable versus unpredictable unpleasant stimuli. Ages 18-40. Location in Bethesda, MD.
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Effects of Arousal and Stress in Anxiety.
Evaluation study. This study has several parts. Ages 18-50. Location in Bethesda, MD.
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Fear Conditioning Using Computer-Generated Virtual Reality.
Evaluation study. The purpose of this study is to use a computer-generated virtual reality environment to study fear conditioning. Ages 7-50. Location in Bethesda, MD.
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Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers.
Evaluation study. The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Mood and Anxiety Disorders Program (MAP) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. Ages 3-85. Location in Bethesda, MD.
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Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes.
Evaluation study. This study uses functional magnetic resonance imaging (fMRI) to learn how the brain functions in adolescents receiving fluoxetine (Prozac) cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) for anxiety or depression in children/adolescents. Ages 8-40. Location in Bethesda, MD.
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Brain Tissue Collection for Neuropathological Studies.
Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
Search ClinicalTrials.gov for other NIH studies on Anxiety Disorders.
